Mesenchymal Stem Cell Therapy
Mesenchymal stem cells are commonly known as the bone marrow stem cells, skeletal stem cells and multipotent mesenchymal stromal cells. These are cells separated from adult tissues and have extensive propagating ability in an unattached state. Moreover, they have the capacity to retain the potential to distinguish from other lineages of mesenchymal origin.
The various adaptive abilities of these cells gave way for mesenchymal stem cell therapy. Mesenchymal stem cells can be isolated from different tissue sources without trouble. They can also be cultured easily and differentiated under suitable stimulation. Mesenchymal stem therapy therefore becomes a subject for its potentials in regenerative medicine.
This therapy obviously uses mesenchymal stem cells in repairing and regenerating cartilage tissue through ex vivo cartilage tissue engineering and in vivo cartilage regeneration. The first method is done through a tissue that will be used in replacing an old one. This replacement tissue is constructed by in vitro mesenchymal stem cells mingled with scaffold under suitable environmental stimuli.
The second approach is done by utilizing the anti-inflammatory and immunosuppressive effects of mesenchymal stem cell therapy. Since these stem cells have regenerative capabilities, they are expected to influence the microenvironment they will be set in so they can assist in the regeneration of cartilage.
Studies are advanced to prove that this kind of therapy can help in the treatment of autoimmune diseases. Furthermore, there are researches in the capacity of mesenchymal stem cell therapy to treat rheumatic diseases. It is seen as a possibility in curing arthritic joint diseases because of the stem cells’ multipotential differentiation capacity and the ease of isolation and expansion proffered by these cells. Moreover, the potential use of mesenchymal stem cells as main components for replacing tissue joint tissue and their potential for direct cell therapy solicit further researches in the scientific community.